A mother and father, ages 35 and 37, and two of their children, ages 5 and 7, were shot in the head in the village of Tammun, while two of their other children sustained injuries, Palestinian health authorities.
The Israeli military said it was looking into the reports.
The Palestinian Health Ministry also said one Palestinian was killed in an attack by settlers overnight.
Israeli settlers in the West Bank are taking advantage of curbs on movement imposed during the US-Israeli war on Iran to attack Palestinians, with military roadblocks preventing ambulances from reaching victims quickly, rights groups and medics say.
Settlers have killed at least five Palestinians in the West Bank since the Iran war began on February 28, according to the Palestinian health ministry.
Talks to advance Trump’s plan to end the Gaza conflict have been on hold since last week when the United States and Israel jointly attacked Iran, sparking a broader Middle East war, three sources with direct knowledge of the negotiations said.
The pause threatens to stall implementation of Trump’s flagship Middle East peace initiative, which he has cast as a major foreign policy objective. It comes less than a month after he secured billions of dollars in pledges for Gaza from Gulf Arab states — countries that are now facing Iranian attacks as the conflict widens.
Trump’s Gaza plan has hinged in part on whether Hamas would lay down their arms in exchange for amnesty, a step intended to pave the way for reconstruction and further Israeli military withdrawals. White House mediators have been backchanneling between Israel and Hamas on the disarmament question.